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Herbs & Supplements

Fenugreek
Other Names: Alhova, Bird's Foot, Greek Clover, Greek Hay, Hu Lu Ba, Methi, Trigonella, Trigonella foenum-graecum

References

Ahsan SK, Tariq M, Ageel AM, al-Yahya MA, Shah AH. Effect of Trigonella foenum-graecum and Ammi majus on calcium oxalate urolithiasis in rats. Journal of Ethnopharmacology. 1989;26(3):249-254.

Annida B, Stanely Mainzen Prince P. Supplementation of fenugreek leaves reduces oxidative stress in streptozotocin-induced diabetic rats. Journal of Medical Food. 2005;8(3):382-385.

Anon: Fenugreek. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. July 1996.

Bartley GB, Hilty MD, Andreson BD, Clairmont AC, Maschke SP. "Maple-syrup" urine odor due to fenugreek ingestion. New England Journal of Medicine. 1981;305(8):467.

Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum [sic] L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins, Leukotrienes and Essential Fatty Acids. 1997;56(5):379-384.

Bradley R, Oberg EB, Calabrese C, Standish LJ. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. Journal of Alternative and Complementary Medicine. 2007;13(1):159-175.

Broca C, Manteghetti M, Gross R, et al. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. European Journal of Pharmacology. 2000;390(3):339-345.

Devasena T, Menon VP. Fenugreek affects the activity of beta-glucuronidase and mucinase in the colon. Phytotherapy Research. 2003;17(9):1088-1091.

Devasena T, Venugopal Menon P. Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. Italian Journal of Biochemistry. 2007;56(1):28-34.

Devi BA, Kamalakkannan N, Prince PS. Supplementation of fenugreek leaves to diabetic rats. Effect on carbohydrate metabolic enzymes in diabetic liver and kidney. Phytotherapy Research. 2003;17(10):1231-1233.

Gad MZ, El-Sawalhi MM, Ismail MF, El-Tanbouly ND. Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites. Molecular and Cellular Biochemistry. 2006;281(1-2):173-183.

Grieve M. Fenugreek. In: A Modern Herbal. New York: Dover Publishers, 1971. Available at: http://www.botanical.com/botanical/mgmh/mgmh.html Posted 1995. Accessed April 11, 2003.

Handa T, Yamaguchi K, Sono Y, Yazawa K. Effects of fenugreek seed extract in obese mice fed a high-fat diet. Bioscience, Biotechnology, and Biochemistry. 2005;69(6):1186-1188.

Hannan JM, Ali L, Rokeya B, et al. Soluble dietary fibre [sic] fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. British Journal of Nutrition. 2007;97(3):514-521.

Hannan JM, Rokeya B, Faruque O, et al. Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats. Journal of Ethnopharmacology. 2003;88(1):73-77.

HealthNotes, Inc. Fenugreek. 2002. Available at: http://www.mycustompak.com/healthNotes/Herb/Fenugreek.htm Accessed March 28, 2003.

Jelodar GA, Maleki M, Motadayen MH, Sirus S. Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian Journal of Medical Science. 2005;59(2):64-69.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Kassem A, Al-Aghbari A, AL-Habori M, Al-Mamary M. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception. 2006;73(3):301-306.

Kaviarasan S, Anuradha CV. Fenugreek (Trigonella foenum graecum) seed polyphenols protect liver from alcohol toxicity: a role on hepatic detoxification system and apoptosis. Pharmazie. 2007;62(4):299-304.

Kaviarasan S, Ramamurty N, Gunasekaran P, Varalakshmi E, Anuradha CV. Fenugreek (Trigonella foenum graecum) seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells. Alcohol and Alcoholism. 2006;41(3):267-273.

Kaviarasan S, Viswanathan P, Anuradha CV. Fenugreek seed (Trigonella foenum graecum) polyphenols inhibit ethanol-induced collagen and lipid accumulation in rat liver. Cell Biology and Toxicology. Epublished ahead of print. April 24, 2007.

Korman SH, Cohen E, Preminger A. Pseudo-maple syrup urine disease due to maternal prenatal ingestion of fenugreek. Journal of Paediatric [sic] and Child Health. 2001;37(4):403-404.

Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy. 2001; 21(4):509-512.

Langmead L, Dawson C, Hawkins C, Banna N, Loo S, Rampton DS. Antioxidant effect of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Alimentary Pharmacology and Therapeutics. 2002;16(2):197-205.

Laroubi A, Touhami M, Farouk L, et al. Prophylaxis effect of Trigonella foenum graecum L. seeds on renal stone formation in rats. Phytotherapy Research. 2007;21(10):921-925.

Lees B. Fenugreek. Alberta Agriculture, Food and Rural Development Agency. Government of Alberta. April 1, 1998. Available at: http://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/agdex124. Accessed February 18, 2004.

Madar Z. New sources of dietary fibre [sic]. International Journal of Obesity. 1987;11(Suppl 1):57-65.

Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. European Journal of Clinical Nutrition. 1988;42(1):51-54.

McCaleb R. Antidiabetic Fenugreek. HerbalGram. 1991. Winter. 24:18.

Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Annals of Allergy, Asthma, and Immunology. 1997;78(3):297-300.

Preet A, Siddiqui MR, Taha A, et al. Long-term effect of Trigonella foenum graecum and its combination with sodium orthovanadate in preventing histopathological and biochemical abnormalities in diabetic rat ocular tissues. Molecular and Cellular Biochemistry. 2006;289(1-2):137-147.

Raju J, Bird RP. Alleviation of hepatic steatosis accompanied by modulation of plasma and liver TNF-alpha levels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. International Journal of Obesity (London). 2006;30(8):1298-1307.

Sauvaire Y, Petit P, Broca C, et al. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes. 1998;47(2):206-210.

Sebastian KS, Thampan RV. Differential effects of soybean and fenugreek extracts on the growth of MCF-7 cells. Chemico-Biological Interactions. 2007;170(2):135-143.

Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. [letter] New England Journal of Medicine. 1999;341(10):769.

Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. European Journal of Clinical Nutrition. 1990;44(4):301-306.

Thirunavukkarasu V, Anuradha CV, Viswanathan P. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytotherapy Research. 2003;17(7):737-743.

Thompson Coon JS, Ernst E. Herbs for serum cholesterol reduction: a systematic view. Journal of Family Practice. 2003;52(6):468-478.

Xue WL, Li XS, Zhang J, Liu YH, Wang ZL, Zhang RJ. Effect of Trigonella foenum-graecum (fenugreek) extract on blood glucose, blood lipid and hemorheological properties in streptozotocin-induced diabetic rats. Asia Pacific Journal of Clinical Nutrition. 2007;16(Suppl 1):422-426.

Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. Journal of Ethnopharmacology. 1997;58(1):45-54.

Last Revised October 11, 2007

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Note: The above information is not intended to replace the advice of your physician, pharmacist, or other healthcare professional. It is not meant to indicate that the use of the product is safe, appropriate, or effective for you.

In general, herbal products are not subject to review or approval by the U.S. Food and Drug Administration (FDA). They are not required to be standardized, meaning that the amounts of active ingredients or contaminants they contain may vary between brands or between different batches of the same brand. Not all of the risks, side effects, or interactions associated with the use of herbal products are known because few reliable studies of their use in humans have been done.

This information is provided for your education only. Please share this information with your healthcare provider and be sure that you talk to your doctor and pharmacist about all the prescription and non-prescription medicines you take before you begin to use any herbal product.

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